Dr. Marina Johnson DIM

In the detoxification process some estrogen metabolites may become more harmful prior to their final elimination from the body. Glucuronic acid is often attached to these metabolites prior to their elimination. Certain gut bacteria are capable of releasing these metabolites via the activity of the glucuronidase enzyme and allowing them to recirculate with potentially harmful consequences. The glucarate delivered by calcium D-glucorate is capable of inhibiting this glucuronidase and reducing the harmful burden of 16-hydroxy estrones on the body.

Human clinical trials show an improvement in 2/16 hydroxy-estrone ratios in women taking I3C, demonstrating its value in helping lower risk in these women.

The proper processing of estrogen metabolites requires folic acid. Folic acid deficiency, especially alcohol-related, increases risk for estrogen-related breast conditions.

Just as in women, men also can have hormone related conditions, most common of which are issues with the prostate. The bodys natural detoxification process can unearth negative consequences where some metabolites may become more harmful prior to their final elimination from the body. Glucuronic acid is often attached to these metabolites prior to their elimination. Certain gut bacteria are capable of releasing these metabolites via the activity of the glucuronidase enzyme and allowing them to recirculate with potentially harmful consequences. The glucarate delivered by calcium D-glucorate is capable of inhibiting this glucuronidase and reducing the harmful burden on the body.

I3C is considered one of the main active ingredients accounting for the health benefits found in cruciferous vegetables. I3C, and many of its metabolites including DIM, have been investigated with in vitro and animal studies using susceptible cell and animal lines.

The proper processing of estrogen metabolites requires folic acid. Folic acid deficiency, especially alcohol-related, increases risk for conditions relating to the prostate.